Small molecular inhibitor-盟基生物科技股份有限公司

Inhibitor & Compound Library

Small molecular inhibitor

Inhibitor & Compound Library

Small molecular inhibitor

小分子抑製劑可以與目標蛋白結合並降低其生物活性，通常用作生物學和藥理學研究的工具。

小分子抑製劑有很多優點。例如，它們易於操作，可應用於各種細胞或動物實驗；它們具有良好的滲透性，容易穿過細胞膜；它們具有高穩定性，可以減少實驗中的不穩定性。小分子抑製劑因其在調節不同細胞過程（從細胞週期控制和有絲分裂到信號通路與基因表達；從遷移和傷口癒合，到細胞凋亡和自噬）方面的顯著優勢而成為近年來生命科學研究的重要工具藥物。

一、產品介紹

Target Molecule Corp. (TargetMol) 是一家全球性的高科技企業，專門從事化學和生物研究產品和服務。 Targetmol 提供超過 7,000 種用於細胞信號路徑研究和藥物發現的化合物，並追踪最新的科學研究，及時提供最新最流行的抑製劑。

二、產品特色

1. 每月推出100-200 種新抑製劑
2. NMR 和 HPLC 驗證以確保高純度
3. 95% 以上的化合物有庫存
4. 具有競爭力的價格
5. 多種期刊引用

TargetMol使用 HPLC 和 HNMR測試質量確保所有產品的最高質量標準。例如，圖中顯示了脂肪抑素(fatostatin)的質量控制報告，其純度經質量檢測達99.84%以上。

註：同樣的產品，與競爭對手相比，Calbiochem (EMD) 的純度達到 95%，TOCRIS 達到 97%，SIGMA 達到 98%。

除了保證最高質量標準外，TargetMol還確保最具競爭力的價格。

TargetMol的產品受到諸多研究者的青睞，被引用在各種期刊之中。詳細的引用文獻資訊可至各個產品頁面查閱。

三、產品類別

熱門研究標的與抑制劑

信號途徑(Signaling Pathways)	標的物	抑制劑
Angiogenesis	JAK	Ruxolitinib,Tofacitinib Citrate,Fedratinib
	EGFR	Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
	HER	Neratinib,Afatinib
	Bcr-Abl	Bosutinib,Ponatinib, Imatinib, Nilotinib, Imatinib Mesylate, Dasatinib
	ALK	LDK378, LDN193189, Crizotinib, SB525334, SB 431542
	FGFR	AZD4547, Ponatinib, Infigratinib, Nintedanib
	FLT	Sunitinib Malate, Crenolanib, Sorafenib, Sorafenib tosylate, Nintedanib, Quizartinib, Cabozantinib, Fedratinib
	VEGFR	AZD4547, Nintedanib, Vandetanib, Regorafenib, Foretinib, Cabozantinib, Sorafenib, Axitinib, Sunitinib Malate, Sorafenib tosylate, Ponatinib
	BTK	Ibrutinib, Saracatinib
	PDGFR	Nintedanib,Imatinib,Crenolanib,Imatinib Mesylate,Ponatinib,Sorafenib,tosylate,Axitinib,Sunitinib Malate,Sorafenib,
	Src	Saracatinib,Ponatinib,Dasatinib,Bosutinib,PRT062607 hydrochloride,Nintedanib,Ibrutinib
	Syk	R406, PRT062607 hydrochloride
Apoptosis	Caspase	Z-VAD(OMe)-FMK
	c-RET	Regorafenib, Cabozantinib, Fedratinib
	BCL	Navitoclax, Obatoclax Mesylate, ABT737, ABT199
	Ferroptosis	Erastin, Ferrostatin-1,Deferoxamine Mesylate
Autophagy	Autophagy	3-Methyladenine, Gemcitabine, Rapamycin
Cell Cycle/Checkpoint	Aurora Kinase	Alisertib, 1H-Pyrazole-3-acetamide, Pyrazolanthrone, Tozasertib
	ROCK	Thiazovivin, Y-27632 dihydrochloride
	CDK	Roscovitine, Dinaciclib, Palbociclib hydrochloride, Palbociclib Isethionate
	Ferroptosis	Erastin, Ferrostatin-1,Deferoxamine Mesylate
	PLK	BI 2536, Volasertib
	Wee1	Adavosertib
	DNA/RNA Synthesis	Temozolomide,Gemcitabine HCl,Resveratrol,Fludarabine,Gemcitabine,Cisplatin,Fluorouracil,
Chromatin/Epigenetic	HDAC	RGFP 966,Entinostat,Vorinostat,Mocetinostat,Panobinostat
	PARP	Veliparib, Olaparib, Talazoparib, Rucaparib Phosphate
	Sirtuin	SRT1720 hydrochloride, Resveratrol, Selisistat
	DNA Methyltransferase	Decitabine
	Epigenetic Reader Domain	BI 2536, (+)-JQ-1
	JAK	Ruxolitinib, Tofacitinib Citrate, Fedratinib
	Aurora Kinase	Alisertib, 1H-Pyrazole-3-acetamide, Pyrazolanthrone, Tozasertib
	PKC	Sotrastaurin
Cytoskeletal Signaling	HSP	Tanespimycin, Luminespib
	Akt	Capivasertib, MK-2206 dihydrochloride
	Wnt/beta-catenin	XAV939
	Microtubule Associated	Vincristine sulfate, Docetaxel, Paclitaxel, Colchicine
	PKC	Sotrastaurin
	Bcr-Abl	Bosutinib,Ponatinib,Imatinib,Nilotinib,Imatinib Mesylate,Dasatinib
	ROCK	Thiazovivin, Y-27632 dihydrochloride
DNA Damage/DNA Repair	ATM/ATR	KU60019, VE821, Dactolisib
	DNA-PK	PI103, LY294002, NU7441
	DNA/RNA Synthesis	Temozolomide,Gemcitabine HCl,Resveratrol,Fludarabine,Gemcitabine,Cisplatin,Fluorouracil,
	Topoisomerase	Doxorubicin hydrochloride, Etoposide
	HDAC	RGFP 966,Entinostat,Vorinostat,Mocetinostat,Panobinostat
	PARP	Veliparib, Olaparib, Talazoparib, Rucaparib Phosphate
	Sirtuin	SRT1720 hydrochloride, Resveratrol, Selisistat
Endocrinology/Hormones	Androgen Receptor	Enzalutamide
	Estrogen/progestogen Receptor	Fulvestrant
	Glucocorticoid Receptor	Dexamethasone
GPCR/G Protein	Adrenergic Receptor	Isoprenaline hydrochloride
	Hedgehog/Smoothened	Vismodegib, Cyclopamine
	S1P Receptor	Fingolimod hydrochloride
Immunology/Inflammation	COX	Resveratrol
	IL Receptor	Dexamethasone
	TLR	Chloroquine diphosphate
JAK/STAT signaling	STAT	Stattic, S3I201, Fludarabine
	EGFR	Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
	HER	Neratinib,Afatinib
	JAK	Ruxolitinib,Tofacitinib Citrate,Fedratinib
MAPK	ERK	Selumetinib, SCH772984
	JNK	Pyrazolanthrone
	MAPK	Vemurafenib
	MEK	SCH772984,U0126-EtOH,Selumetinib,PD 98059,CI1040,Trametinib,PD0325901
	MLK	PRT062607 hydrochloride
	p38 MAPK	SB202190, SB203580, Doramapimod
	Raf	Vemurafenib,Regorafenib,Sorafenib tosylate,PLX4720,Sorafenib,Dabrafenib
	S6 Kinase	H 89 2HCl, BI-D1870
Membrane transporter/Ion channel	ABC	Vismodegib
Membrane transporter/Ion channel	CFTR	Lumacaftor, Ivacaftor
Metabolism	Casein Kinase	Silmitasertib
	Lipoxygenase	Resveratrol
	NADPH	Resveratrol
	PDE	IBMX, Isoprenaline hydrochloride
	HSP	Tanespimycin, Luminespib
	Amino Acids and Derivatives	Pepstatin
Neuroscience	Gamma-secretase	DAPT, RO4929097
	Adrenergic Receptor	Isoprenaline hydrochloride
	AChR	Forskolin
	Beta Amyloid	DAPT, RO4929097
	COX	Resveratrol
NF-Κb	IκB/IKK	Resveratrol
PI3K/Akt/mTOR signaling	GSK-3	CHIR99021
	AMPK	Metformin hydrochloride
	mTOR	Dactolisib,Tacrolimus,Capivasertib,Everolimus,Torkinib,PI103,Temsirolimus,AZD8055,Rapamycin
	PI3K	PI103,Buparlisib,Isoprenaline hydrochloride,LY294002 ,3-Methyladenine,Pictilisib,Torkinib,Idelalisib,Alpelisib,Dactolisib
	S6 Kinase	H 89 2HCl, BI-D1870
	Akt	Capivasertib, MK-2206 dihydrochloride
	ATM/ATR	KU60019, VE821, Dactolisib
	DNA-PK	PI103, LY294002, NU7441
Proteases/Proteasome	Proteasome	MG132, Bortezomib
	Cysteine Protease	MG132
	Serine Protease	LDK378
	Caspase	Z-VAD(OMe)-FMK
	Gamma-secretase	DAPT, RO4929097
Stem Cells	TGF-beta/Smad	LY2109761, SB525334, Galunisertib
	ROCK	Thiazovivin, Y-27632 dihydrochloride
	Wnt/beta-catenin	XAV939
	Hedgehog/Smoothened	Vismodegib, Cyclopamine
	STAT	Stattic, S3I201, Fludarabine
	Casein Kinase	Silmitasertib
	GSK-3	CHIR99021
	Gamma-secretase	DAPT, RO4929097
	JAK	Ruxolitinib,Tofacitinib Citrate,Fedratinib
Tyrosine Kinase/Adaptors	c-Kit	Dasatinib,Saracatinib,Cabozantinib,Ponatinib,Sorafenib tosylate,Sunitinib Malate,Imatinib ,Regorafenib,Imatinib Mesylate,Sorafenib,Axitinib
	c-Met/HGFR	Cabozantinib,Crizotinib,Foretinib
	IGF-1R	LDK378
	Src	Saracatinib,Ponatinib,Dasatinib,Bosutinib,PRT062607 hydrochloride,Nintedanib,Ibrutinib
	TAM Receptor	Bemcentinib, Cabozantinib
	Tie-2	Foretinib
	Trk receptor	Pyrazolanthrone
	ALK	LDK378, LDN193189, Crizotinib, SB525334, SB 431542
	FGFR	AZD4547, Ponatinib, Infigratinib, Nintedanib
	FLT	Sunitinib Malate, Crenolanib, Sorafenib, Sorafenib tosylate, Nintedanib, Quizartinib, Cabozantinib, Fedratinib
	VEGFR	AZD4547, Nintedanib, Vandetanib, Regorafenib, Foretinib, Cabozantinib, Sorafenib, Axitinib, Sunitinib Malate, Sorafenib tosylate, Ponatinib
	c-RET	Regorafenib, Cabozantinib, Fedratinib
	EGFR	Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
	HER	Neratinib,Afatinib
	BTK	Ibrutinib, Saracatinib
	PKA	Capivasertib, H 89 2HCl
	Tyrosine Kinases	Ruxolitinib,Gefitinib,Ibrutinib,Vemurafenib
	ACK	Vemurafenib
	Bcr-Abl	Bosutinib,Ponatinib, Imatinib, Nilotinib, Imatinib Mesylate, Dasatinib
	PDGFR	Nintedanib,Imatinib,Crenolanib,Imatinib Mesylate,Ponatinib,Sorafenib,tosylate,Axitinib,Sunitinib Malate,Sorafenib,
	Syk	R406, PRT062607 hydrochloride
Ubiquitination	Syk	R406, PRT062607 hydrochloride
Ubiquitination	Proteasome	MG132, Bortezomib

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